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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
21.82
Human Site:
S470
Identified Species:
34.29
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S470
E
I
A
F
G
R
Y
S
D
S
L
V
Q
K
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S470
E
I
A
F
G
R
Y
S
D
S
L
V
Q
K
G
Dog
Lupus familis
XP_531814
1283
145094
Q444
R
V
I
T
K
G
T
Q
T
Y
S
V
L
E
G
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S469
E
I
A
F
G
R
F
S
D
S
L
V
Q
K
G
Rat
Rattus norvegicus
XP_002726765
1361
151628
S472
E
I
A
F
G
R
F
S
D
S
L
V
Q
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
R576
F
P
E
T
A
F
G
R
F
S
A
I
L
V
Q
Frog
Xenopus laevis
NP_001089247
1340
149481
S449
E
I
A
F
G
R
F
S
D
V
L
V
Q
K
G
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
S469
E
I
G
F
G
R
F
S
D
V
L
V
Q
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
R365
K
F
D
K
V
V
A
R
E
I
C
Q
I
T
N
Honey Bee
Apis mellifera
XP_392346
1120
127429
V295
L
I
E
R
G
Y
K
V
A
R
V
E
Q
T
E
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
G361
V
C
R
V
T
S
N
G
T
R
T
Y
G
V
L
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
D442
F
V
P
K
S
F
M
D
K
T
T
P
A
M
R
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
A451
T
E
S
R
Q
S
L
A
N
Q
G
L
E
R
I
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
I443
E
K
N
F
S
V
N
I
E
K
L
V
R
K
G
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
I417
V
K
R
E
L
Q
C
I
L
T
S
G
T
L
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
13.3
N.A.
93.3
93.3
N.A.
N.A.
6.6
86.6
80
N.A.
0
20
0
0
P-Site Similarity:
100
N.A.
100
26.6
N.A.
100
100
N.A.
N.A.
13.3
93.3
86.6
N.A.
13.3
26.6
0
13.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
0
N.A.
N.A.
40
0
N.A.
P-Site Similarity:
40
N.A.
N.A.
53.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
34
0
7
0
7
7
7
0
7
0
7
0
0
% A
% Cys:
0
7
0
0
0
0
7
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
7
0
0
0
0
7
40
0
0
0
0
0
0
% D
% Glu:
47
7
14
7
0
0
0
0
14
0
0
7
7
7
7
% E
% Phe:
14
7
0
47
0
14
27
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
7
0
47
7
7
7
0
0
7
7
7
0
54
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
47
7
0
0
0
0
14
0
7
0
7
7
0
7
% I
% Lys:
7
14
0
14
7
0
7
0
7
7
0
0
0
47
0
% K
% Leu:
7
0
0
0
7
0
7
0
7
0
47
7
14
7
7
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
7
0
0
0
14
0
7
0
0
0
0
0
7
% N
% Pro:
0
7
7
0
0
0
0
0
0
0
0
7
0
0
0
% P
% Gln:
0
0
0
0
7
7
0
7
0
7
0
7
47
0
7
% Q
% Arg:
7
0
14
14
0
40
0
14
0
14
0
0
7
7
7
% R
% Ser:
0
0
7
0
14
14
0
40
0
34
14
0
0
0
0
% S
% Thr:
7
0
0
14
7
0
7
0
14
14
14
0
7
14
7
% T
% Val:
14
14
0
7
7
14
0
7
0
14
7
54
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
14
0
0
7
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _